NEDD4L Full-Length MS Protein Standard


Product Description:

Name NEDD4L Full-Length MS Protein Standard
Cat# CPFL327866
Protein Nameneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
SymbolNEDD4L
SynonymshNEDD4-2; NEDD4-2; NEDD4.2; RSP5
AccessionNM_001144964
Cytogenetic18q21.31
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW98.2 kDa
Expression TrueORF CloneRC227866
DescriptionNEDD4L Full-Length MS Protein Standard (NP_001138436), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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