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GFRA1 Full-Length MS Protein Standard

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Product Description


NameGFRA1 Full-Length MS Protein Standard
Cat#CPFL326704
Protein NameGDNF family receptor alpha 1
SymbolGFRA1
SynonymsGDNFR; GDNFRA; GFR-ALPHA-1; RET1L; RETL1; TRNR1
AccessionNM_001145453
Cytogenetic10q26.11
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionGFRA1 Full-Length MS Protein Standard (NP_001138925), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene.

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