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EIF2AK2 Full-Length MS Protein Standard

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Product Description


NameEIF2AK2 Full-Length MS Protein Standard
Cat#CPFL326606
Protein Nameeukaryotic translation initiation factor 2-alpha kinase 2
SymbolEIF2AK2
SynonymsEIF2AK1; PKR; PPP1R83; PRKR
AccessionNM_001135651
Cytogenetic2p22-p21
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionEIF2AK2 Full-Length MS Protein Standard (NP_001129123), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.

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