PFKFB1 Full-Length MS Protein Standard


Product Description:

Name PFKFB1 Full-Length MS Protein Standard
Cat# CPFL324599
Protein Name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
SymbolPFKFB1
SynonymsF6PK; HL2K; PFRX
AccessionNM_002625
CytogeneticXp11.21
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW54.5 kDa
Expression TrueORF CloneRC224599
DescriptionPFKFB1 Full-Length MS Protein Standard (NP_002616), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.

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