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TRIOBP Full-Length MS Protein Standard

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Product Description


NameTRIOBP Full-Length MS Protein Standard
Cat#CPFL324094
Protein NameTRIO and F-actin binding protein
SymbolTRIOBP
SynonymsDFNB28; dJ37E16.4; HRIHFB2122; TAP68; TARA
AccessionNM_138632
Cytogenetic22q13.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionTRIOBP Full-Length MS Protein Standard (NP_619538), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD).

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