BCL11A Full-Length MS Protein Standard


Product Description:

Name BCL11A Full-Length MS Protein Standard
Cat# CPFL323575
Protein NameB-cell CLL/lymphoma 11A (zinc finger protein)
SymbolBCL11A
SynonymsBCL11A-L; BCL11a-M; BCL11A-S; BCL11A-XL; CTIP1; EVI9; HBFQTL5; ZNF856
AccessionNM_138559
Cytogenetic2p16.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW26.7 kDa
Expression TrueORF CloneRC223575
DescriptionBCL11A Full-Length MS Protein Standard (NP_612569), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.

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