GAD2 Full-Length MS Protein Standard


Product Description:

Name GAD2 Full-Length MS Protein Standard
Cat# CPFL323464
Protein Nameglutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
SymbolGAD2
SynonymsGAD65
AccessionNM_000818
Cytogenetic10p11.23
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW65.2 kDa
Expression TrueORF CloneRC223464
DescriptionGAD2 Full-Length MS Protein Standard (NP_000809), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

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