| Name | TMEM189 Full-Length MS Protein Standard |
|---|---|
| Cat# | CPFL323133 |
| Protein Name | transmembrane protein 189 |
| Symbol | TMEM189 |
| Synonyms | CROC-1B; CROC1B; KUA-UEV |
| Accession | NM_199203 |
| Cytogenetic | 20q13.2 |
| Amino Acid Labeled | [U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys |
| Chemical Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Expression Host | Human HEK293 cells |
| Predicted MW | 42 kDa |
| Expression TrueORF Clone | RC223133 |
| Description | TMEM189 Full-Length MS Protein Standard (NP_954673), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. |
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