CYP27A1 Full-Length MS Protein Standard


Product Description:

Name CYP27A1 Full-Length MS Protein Standard
Cat# CPFL322953
Protein Namecytochrome P450, family 27, subfamily A, polypeptide 1
SymbolCYP27A1
SynonymsCP27; CTX; CYP27
AccessionNM_000784
Cytogenetic2q35
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW56.9 kDa
Expression TrueORF CloneRC222953
DescriptionCYP27A1 Full-Length MS Protein Standard (NP_000775), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease.

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