FMR1 Full-Length MS Protein Standard


Product Description:

Name FMR1 Full-Length MS Protein Standard
Cat# CPFL322699
Protein Namefragile X mental retardation 1
SymbolFMR1
SynonymsFMRP; FRAXA; POF; POF1; POFX
AccessionNM_002024
CytogeneticXq27.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW71 kDa
Expression TrueORF CloneRC222699
DescriptionFMR1 Full-Length MS Protein Standard (NP_002015), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5 UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.

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