GNE Full-Length MS Protein Standard


Product Description:

Name GNE Full-Length MS Protein Standard
Cat# CPFL322626
Protein Nameglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
SymbolGNE
SynonymsDMRV; GLCNE; IBM2; NM; Uae1
AccessionNM_005476
Cytogenetic9p13.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW79.1 kDa
Expression TrueORF CloneRC222626
DescriptionGNE Full-Length MS Protein Standard (NP_005467), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.

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