ITGA2B Full-Length MS Protein Standard


Product Description:

Name ITGA2B Full-Length MS Protein Standard
Cat# CPFL322614
Protein Nameintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
SymbolITGA2B
SynonymsBDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb; GT; GTA; HPA3; PPP1R93
AccessionNM_000419
Cytogenetic17q21.32
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW110 kDa
Expression TrueORF CloneRC222614
DescriptionITGA2B Full-Length MS Protein Standard (NP_000410), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

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