GRIK2 Full-Length MS Protein Standard


Product Description:

Name GRIK2 Full-Length MS Protein Standard
Cat# CPFL322369
Protein Nameglutamate receptor, ionotropic, kainate 2
SymbolGRIK2
SynonymsEAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6
AccessionNM_021956
Cytogenetic6q16.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW98.9 kDa
Expression TrueORF CloneRC222369
DescriptionGRIK2 Full-Length MS Protein Standard (NP_068775), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation.

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