IL12RB1 Full-Length MS Protein Standard


Product Description:

Name IL12RB1 Full-Length MS Protein Standard
Cat# CPFL321974
Protein Nameinterleukin 12 receptor, beta 1
SymbolIL12RB1
SynonymsCD212; IL-12R-BETA1; IL12RB; IMD30
AccessionNM_005535
Cytogenetic19p13.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW70.4 kDa
Expression TrueORF CloneRC221974
DescriptionIL12RB1 Full-Length MS Protein Standard (NP_005526), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.

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