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DPH1 Full-Length MS Protein Standard

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Product Description


NameDPH1 Full-Length MS Protein Standard
Cat#CPFL321955
Protein NameDPH1 DPH1 homolog (S. cerevisiae)
SymbolDPH1
SynonymsDPH2L; DPH2L1; OVCA1
AccessionNM_001383
Cytogenetic17p13.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionDPH1 Full-Length MS Protein Standard (NP_001374), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 )

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