TYR Full-Length MS Protein Standard


Product Description:

Name TYR Full-Length MS Protein Standard
Cat# CPFL321797
Protein Nametyrosine
SymbolTYR
SynonymsATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3
AccessionNM_000372
Cytogenetic11q14.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW58.3 kDa
Expression TrueORF CloneRC221797
DescriptionTYR Full-Length MS Protein Standard (NP_000363), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3 half of this gene.

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