BCL2L12 Full-Length MS Protein Standard


Product Description:

Name BCL2L12 Full-Length MS Protein Standard
Cat# CPFL321347
Protein NameBCL2-like 12 (proline rich)
SymbolBCL2L12
SynonymsMGC120313; MGC120314; MGC120315
AccessionNM_138639
Cytogenetic19q13.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW36.6 kDa
Expression TrueORF CloneRC221347
DescriptionBCL2L12 Full-Length MS Protein Standard (NP_619580), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants.

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