CYP2C9 Full-Length MS Protein Standard


Product Description:

Name CYP2C9 Full-Length MS Protein Standard
Cat# CPFL320997
Protein Namecytochrome P450, family 2, subfamily C, polypeptide 9
SymbolCYP2C9
SynonymsCPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9
AccessionNM_000771
Cytogenetic10q24
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW55.4 kDa
Expression TrueORF CloneRC220997
DescriptionCYP2C9 Full-Length MS Protein Standard (NP_000762), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

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