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APOBEC3A Full-Length MS Protein Standard

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Product Description


NameAPOBEC3A Full-Length MS Protein Standard
Cat#CPFL320995
Protein Nameapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
SymbolAPOBEC3A
SynonymsA3A; ARP3; bK150C2.1; PHRBN
AccessionNM_145699
Cytogenetic22q13.1-q13.2
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionAPOBEC3A Full-Length MS Protein Standard (NP_663745), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene.

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