KIAA0226 Full-Length MS Protein Standard


Product Description:

Name KIAA0226 Full-Length MS Protein Standard
Cat# CPFL320593
Protein NameKIAA0226
SymbolKIAA0226
SynonymsRUBICON; SCAR15
AccessionNM_014687
Cytogenetic3q29
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW108.4 kDa
Expression TrueORF CloneRC220593
DescriptionKIAA0226 Full-Length MS Protein Standard (NP_055502), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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