ERBB4 Full-Length MS Protein Standard


Product Description:

Name ERBB4 Full-Length MS Protein Standard
Cat# CPFL320500
Protein Namev-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
SymbolERBB4
SynonymsALS19; HER4; p180erbB4
AccessionNM_001042599
Cytogenetic2q33.3-q34
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW142.6 kDa
Expression TrueORF CloneRC220500
DescriptionERBB4 Full-Length MS Protein Standard (NP_001036064), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

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