RCAN1 Full-Length MS Protein Standard


Product Description:

Name RCAN1 Full-Length MS Protein Standard
Cat# CPFL320434
Protein Nameregulator of calcineurin 1
SymbolRCAN1
SynonymsADAPT78; CSP1; DSC1; DSCR1; MCIP1; RCN1
AccessionNM_004414
Cytogenetic21q22.12
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW27.9 kDa
Expression TrueORF CloneRC220434
DescriptionRCAN1 Full-Length MS Protein Standard (NP_004405), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants.

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