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PCSK9 Full-Length MS Protein Standard

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Product Description


NamePCSK9 Full-Length MS Protein Standard
Cat#CPFL320000
Protein Nameproprotein convertase subtilisin/kexin type 9
SymbolPCSK9
SynonymsFH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9
AccessionNM_174936
Cytogenetic1p32.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionPCSK9 Full-Length MS Protein Standard (NP_777596), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.

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