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TNFRSF18 Full-Length MS Protein Standard

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Product Description


NameTNFRSF18 Full-Length MS Protein Standard
Cat#CPFL319997
Protein Nametumor necrosis factor receptor superfamily, member 18
SymbolTNFRSF18
SynonymsAITR; CD357; GITR; GITR-D
AccessionNM_004195
Cytogenetic1p36.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionTNFRSF18 Full-Length MS Protein Standard (NP_004186), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

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