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IDUA Full-Length MS Protein Standard

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Product Description


NameIDUA Full-Length MS Protein Standard
Cat#CPFL319336
Protein Nameiduronidase, alpha-L-
SymbolIDUA
SynonymsIDA; MPS1
AccessionNM_000203
Cytogenetic4p16.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionIDUA Full-Length MS Protein Standard (NP_000194), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I).

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