| Name | IDUA Full-Length MS Protein Standard |
|---|---|
| Cat# | CPFL319336 |
| Protein Name | iduronidase, alpha-L- |
| Symbol | IDUA |
| Synonyms | IDA; MPS1 |
| Accession | NM_000203 |
| Cytogenetic | 4p16.3 |
| Amino Acid Labeled | [U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys |
| Chemical Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Expression Host | Human HEK293 cells |
| Predicted MW | 70 kDa |
| Expression TrueORF Clone | RC219336 |
| Description | IDUA Full-Length MS Protein Standard (NP_000194), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). |
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