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EDARADD Full-Length MS Protein Standard

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Product Description


NameEDARADD Full-Length MS Protein Standard
Cat#CPFL319198
Protein NameEDAR (ectodysplasin-A receptor)-associated death domain
SymbolEDARADD
SynonymsECTD11A; ECTD11B; ED3; EDA3
AccessionNM_080738
Cytogenetic1q42.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionEDARADD Full-Length MS Protein Standard (NP_542776), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

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