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KTELC1 Full-Length MS Protein Standard

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Product Description


NameKTELC1 Full-Length MS Protein Standard
Cat#CPFL319177
Protein Namekinase suppressor of ras 2
SymbolKTELC1
SynonymsCLP46, MDSRP, C3orf9, MDS010, hCLP46, KDELCL1, MGC32995
AccessionNM_020231
Cytogenetic3q13.33
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionKTELC1 Full-Length MS Protein Standard (NP_064616), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a protein with both O-glucosyltransferase and O-xylosyltransferase activity which localizes to the lumen of the endoplasmic reticulum. This protein has a carboxy-terminal KTEL motif which is predicted to function as an endoplasmic reticulum retention signal. This gene is an essential regulator of Notch signalling and likely plays a role in cell fate and tissue formation during development. It may also play a role in the pathogenesis of leukemia. Mutations in this gene have been associated with the autosomal dominant genodermatosis Dowling-Degos disease 4. Alternative splicing results in multiple transcript variants.

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