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CHIT1 Full-Length MS Protein Standard

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Product Description


NameCHIT1 Full-Length MS Protein Standard
Cat#CPFL319169
Protein Namechitinase 1 (chitotriosidase)
SymbolCHIT1
SynonymsCHI3; CHIT; CHITD
AccessionNM_003465
Cytogenetic1q32.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionCHIT1 Full-Length MS Protein Standard (NP_003456), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.

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