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TRMU Full-Length MS Protein Standard

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Product Description


NameTRMU Full-Length MS Protein Standard
Cat#CPFL319032
Protein NametRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
SymbolTRMU
SynonymsMTO2; MTU1; TRMT; TRMT1; TRNT1
AccessionNM_018006
Cytogenetic22q13
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionTRMU Full-Length MS Protein Standard (NP_060476), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants.

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