BCL6 Full-Length MS Protein Standard


Product Description:

Name BCL6 Full-Length MS Protein Standard
Cat# CPFL319007
Protein NameB-cell CLL/lymphoma 6
SymbolBCL6
SynonymsBCL5; BCL6A; LAZ3; ZBTB27; ZNF51
AccessionNM_001706
Cytogenetic3q27
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW78.7 kDa
Expression TrueORF CloneRC219007
DescriptionBCL6 Full-Length MS Protein Standard (NP_001697), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

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