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RBFOX1 Full-Length MS Protein Standard

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Product Description


NameRBFOX1 Full-Length MS Protein Standard
Cat#CPFL317960
Protein NameRNA binding protein, fox-1 homolog (C. elegans) 1
SymbolRBFOX1
Synonyms2BP1; A2BP1; FOX-1; FOX1; HRNBP1
AccessionNM_018723
Cytogenetic16p13.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionA2BP1 Full-Length MS Protein Standard (NP_061193), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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