QDPR Full-Length MS Protein Standard


Product Description:

Name QDPR Full-Length MS Protein Standard
Cat# CPFL317737
Protein Namequinoid dihydropteridine reductase
SymbolQDPR
SynonymsDHPR; PKU2; SDR33C1
AccessionNM_000320
Cytogenetic4p15.31
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW25.6 kDa
Expression TrueORF CloneRC217737
DescriptionQDPR Full-Length MS Protein Standard (NP_000311), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase.

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