|Name||MYBPC3 Full-Length MS Protein Standard|
|Protein Name||myosin binding protein C, cardiac|
|Synonyms||CMD1MM; CMH4; FHC; LVNC10; MYBP-C|
|Amino Acid Labeled||[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys|
|Description||MYBPC3 Full-Length MS Protein Standard (NP_000247), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.|
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