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TSHB Full-Length MS Protein Standard

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Product Description


NameTSHB Full-Length MS Protein Standard
Cat#CPFL316914
Protein Namethyroid stimulating hormone, beta
SymbolTSHB
SynonymsTSH-B; TSH-BETA
AccessionNM_000549
Cytogenetic1p13
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionTSHB Full-Length MS Protein Standard (NP_000540), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimotos thyroiditis. Alternative splicing of this gene results in multiple transcript variants.

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