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DPYD Full-Length MS Protein Standard

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Product Description


NameDPYD Full-Length MS Protein Standard
Cat#CPFL316374
Protein Namedihydropyrimidine dehydrogenase
SymbolDPYD
SynonymsDHP; DHPDHASE; DPD
AccessionNM_000110
Cytogenetic1p22
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionDPYD Full-Length MS Protein Standard (NP_000101), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.

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