UPF2 Full-Length MS Protein Standard


Product Description:

Name UPF2 Full-Length MS Protein Standard
Cat# CPFL315944
Protein NameUPF2 regulator of nonsense transcripts homolog (yeast)
SymbolUPF2
SynonymsHUPF2; RENT2; smg-3
AccessionNM_080599
Cytogenetic10p14-p13
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW147.6 kDa
Expression TrueORF CloneRC215944
DescriptionUPF2 Full-Length MS Protein Standard (NP_542166), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.

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