IAPP Full-Length MS Protein Standard


Product Description:

Name IAPP Full-Length MS Protein Standard
Cat# CPFL315074
Protein NameIslet amyloid polypeptide
SymbolIAPP
SynonymsDAP; IAP
AccessionNM_000415
Cytogenetic12p12.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW3.9 kDa
Expression TrueORF CloneRC215074
DescriptionIAPP Full-Length MS Protein Standard (NP_000406), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimers disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.

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