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EIF2AK3 Full-Length MS Protein Standard

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Product Description


NameEIF2AK3 Full-Length MS Protein Standard
Cat#CPFL314993
Protein Nameeukaryotic translation initiation factor 2-alpha kinase 3
SymbolEIF2AK3
SynonymsPEK; PERK; WRS
AccessionNM_004836
Cytogenetic2p12
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionEIF2AK3 Full-Length MS Protein Standard (NP_004827), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

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