IGF1R Full-Length MS Protein Standard


Product Description:

Name IGF1R Full-Length MS Protein Standard
Cat# CPFL314928
Protein Nameinsulin-like growth factor 1 receptor
SymbolIGF1R
SynonymsCD221; IGFIR; IGFR; JTK13
AccessionNM_000875
Cytogenetic15q26.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW81 kDa
Expression TrueORF CloneRC214928
DescriptionIGF1R Full-Length MS Protein Standard (NP_000866), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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