TNNI3 Full-Length MS Protein Standard


Product Description:

Name TNNI3 Full-Length MS Protein Standard
Cat# CPFL314740
Protein Nametroponin I type 3 (cardiac)
SymbolTNNI3
SynonymsCMD1FF; CMD2A; CMH7; cTnI; RCM1; TNNC1
AccessionNM_000363
Cytogenetic19q13.4
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW23.8 kDa
Expression TrueORF CloneRC214740
DescriptionTNNI3 Full-Length MS Protein Standard (NP_000354), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

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