UGT1A8 Full-Length MS Protein Standard


Product Description:

Name UGT1A8 Full-Length MS Protein Standard
Cat# CPFL314521
Protein NameUDP glycosyltransferase 1 family, polypeptide A8
SymbolUGT1A8
SynonymsUDPGT; UDPGT 1-8; UGT-1H; UGT1-08; UGT1.8; UGT1A8S; UGT1H
AccessionNM_019076
Cytogenetic2q37
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW57.1 kDa
Expression TrueORF CloneRC214521
DescriptionUGT1A8 Full-Length MS Protein Standard (NP_061949), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids.

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