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YAF2 Full-Length MS Protein Standard

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Product Description


NameYAF2 Full-Length MS Protein Standard
Cat#CPFL314071
Protein NameYY1 associated factor 2
SymbolYAF2
SynonymsDKFZp779H1820; MGC41856
AccessionNM_005748
Cytogenetic12q12
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionYAF2 Full-Length MS Protein Standard (NP_005739), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1. Multiple alternatively spliced transcript variants have been found for this gene.

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