CYP2E1 Full-Length MS Protein Standard


Product Description:

Name CYP2E1 Full-Length MS Protein Standard
Cat# CPFL313502
Protein Namecytochrome P450, family 2, subfamily E, polypeptide 1
SymbolCYP2E1
SynonymsCPE1; CYP2E; P450-J; P450C2E
AccessionNM_000773
Cytogenetic10q26.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW56.7 kDa
Expression TrueORF CloneRC213502
DescriptionCYP2E1 Full-Length MS Protein Standard (NP_000764), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

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