AIRE Full-Length MS Protein Standard


Product Description:

Name AIRE Full-Length MS Protein Standard
Cat# CPFL313497
Protein Nameautoimmune regulator
SymbolAIRE
SynonymsAIRE1; APECED; APS1; APSI; PGA1
AccessionNM_000383
Cytogenetic21q22.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW57.5 kDa
Expression TrueORF CloneRC213497
DescriptionAIRE Full-Length MS Protein Standard (NP_000374), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).

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