BBC3 Full-Length MS Protein Standard


Product Description:

Name BBC3 Full-Length MS Protein Standard
Cat# CPFL313203
Protein NameBCL2 binding component 3
SymbolBBC3
SynonymsJFY-1; JFY1; PUMA
AccessionNM_014417
Cytogenetic19q13.3-q13.4
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW20.4 kDa
Expression TrueORF CloneRC213203
DescriptionBBC3 Full-Length MS Protein Standard (NP_055232), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.

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