NTRK1 Full-Length MS Protein Standard


Product Description:

Name NTRK1 Full-Length MS Protein Standard
Cat# CPFL313091
Protein Nameneurotrophic tyrosine kinase, receptor, type 1
SymbolNTRK1
SynonymsMTC; p140-TrkA; TRK; Trk-A; TRK1; TRKA
AccessionNM_001012331
Cytogenetic1q21-q22
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW86.7 kDa
Expression TrueORF CloneRC213091
DescriptionNTRK1 Full-Length MS Protein Standard (NP_001012331), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

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