Product Description:

Name	DNMT3A Full-Length MS Protein Standard
Cat#	CPFL313064
Protein Name	DNA (cytosine-5-)-methyltransferase 3 alpha
Symbol	DNMT3A
Synonyms	DNMT3A2; M.HsaIIIA; TBRS
Accession	NM_022552
Cytogenetic	2p23
Amino Acid Labeled	[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression Host	Human HEK293 cells
Predicted MW	101.7 kDa
Expression TrueORF Clone	RC213064
Description	DNMT3A Full-Length MS Protein Standard (NP_072046), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

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