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DNMT3A Full-Length MS Protein Standard


Product Description

NameDNMT3A Full-Length MS Protein Standard
Protein NameDNA (cytosine-5-)-methyltransferase 3 alpha
SynonymsDNMT3A2; M.HsaIIIA; TBRS
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW101.7 kDa
Expression TrueORF CloneRC213064
DescriptionDNMT3A Full-Length MS Protein Standard (NP_072046), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

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