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EIF4G1 Full-Length MS Protein Standard

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Product Description


NameEIF4G1 Full-Length MS Protein Standard
Cat#CPFL312877
Protein Nameeukaryotic translation initiation factor 4 gamma, 1
SymbolEIF4G1
SynonymsEIF-4G1; EIF4F; EIF4G; EIF4GI; P220; PARK18
AccessionNM_004953
Cytogenetic3q27.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionEIF4G1 Full-Length MS Protein Standard (NP_004944), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.

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