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RASGRP1 Full-Length MS Protein Standard

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Product Description


NameRASGRP1 Full-Length MS Protein Standard
Cat#CPFL312473
Protein NameRAS guanyl releasing protein 1 (calcium and DAG-regulated)
SymbolRASGRP1
SynonymsCALDAG-GEFI; CALDAG-GEFII; hRasGRP1; RASGRP; V
AccessionNM_005739
Cytogenetic15q14
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionRASGRP1 Full-Length MS Protein Standard (NP_005730), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).

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