CYP2C19 Full-Length MS Protein Standard


Product Description:

Name CYP2C19 Full-Length MS Protein Standard
Cat# CPFL311377
Protein Namecytochrome P450, family 2, subfamily C, polypeptide 19
SymbolCYP2C19
SynonymsCPCJ; CYP2C; CYPIIC17; CYPIIC19; P450C2C; P450IIC19
AccessionNM_000769
Cytogenetic10q24
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW55.8 kDa
Expression TrueORF CloneRC211377
DescriptionCYP2C19 Full-Length MS Protein Standard (NP_000760), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

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